BRCA 1 and BRCA 2 are two key fighters in the war against cancer. These genes are known as tumor suppressors because they prevent breast, ovarian, and other types of cells from developing and dividing too quickly or uncontrollably when they are functioning properly. Any change or mutation in any of the aforementioned genes impairs this normal function.

Every woman possesses the BRCA 1 and BRCA 2 genes, but only a small percentage of them have mutations. If one of your parents carries the BRCA 1 or BRCA 2 gene mutation, your risk of developing breast cancer or ovarian cancer increases.

Although not every woman with a BRCA 1 or BRCA 2 gene mutation will get breast or ovarian cancer, having one of these mutations also doesn't make you less likely to have these diseases.

According to statistics, 30 out of 100 women will develop ovarian cancer by the time they are 70 years old, and 50 out of 100 women with BRCA gene mutations are likely to develop breast cancer at this time.

How are these mutations going to be found in a woman? Genetic testing provides the solution. BRCA 1 and BRCA 2 gene mutations are searched for during genetic testing for hereditary breast cancer. The next crucial step after genetic testing is genetic counseling, which is essential enough to comprehend test results and inform subsequent actions.

The BRCA gene test is a blood examination that utilizes DNA analysis to find problematic variations (mutations) in either of the two genes that increase the risk of developing breast cancer, BRCA1 or BRCA2. Anyone with a personal or family history of breast cancer or ovarian cancer is advised to get their BRCA gene tested.

Who should think about getting a BRCA gene test?

It is particularly carried out for people who are more likely to have a hereditary gene mutation that raises the risk of breast and ovarian cancer, as well as if you have:

• An individual's history of breast cancer before age 45.
• One or more relatives who have breast cancer, a personal history of breast cancer diagnosed before age 50 and a second primary breast cancer, or a limited or unrecorded family medical history.
• Having had triple-negative breast cancer at age 60 or younger.
• A personal history of at least two different cancers.
• A personal ovarian cancer history.
• Two or more blood relatives, such as your parents, siblings, or children, have a history of breast cancer in their early years.
• A family member who carries the BRCA1 or BRCA2 mutation.
• A family or relatives with a cancer history.

There might be further genetic tests to take into account, though. Based on your personal and family history, a genetic counselor can assist you in deciding what additional genetic testing options could be available.

Those who have inherited a risky BRCA1 or BRCA2 variation have a number of alternatives for lowering their risk of developing cancer. These include improved screening, chemoprevention, and risk-reducing surgery (also known as prophylactic surgery).

Breast cancers with detrimental BRCA1 variations are more likely to be "triple-negative cancers" (that is, the breast cancer cells do not exhibit estrogen receptors, progesterone receptors, or significant quantities of HER2/neu protein) than unpredictable breast cancers or breast cancers with damaging BRCA2 variants. Compared to other kinds of breast cancer, triple-negative malignancies are more difficult to treat and have a worse prognosis.